Selected Genetic Publications:
Hill SY, Rompala GR, Homanics GE, Zezza N. Cross-generational effects of alcohol dependence in humans on HRAS and TP53 methylation in offspring. Epigenomics 9:1189-1203, 2017. PMID:28799801 Read Article
Hill SY, Jones BL, Zezza N, Stiffler S. ACN9 and alcohol dependence: Family-based association analysis in multiplex alcohol dependence families. Am J Med Genet Part B (Neuropsychiatr Genet) 168B: 179-187, 2015. PMID 25821040 Read Article
Lichenstein, SD, Jones BL, O’Brien JW, Zezza N, Stiffler S, Holmes B, Hill SY. Familial risk for alcohol dependence and developmental changes in BMI: the moderating influence of addiction and obesity genes. Pharmocogenomics 15: 1311-1321, 2014. PMID: 25155933 Read Article
O’Brien JW, Lichenstein SD, Hill SY. Maladaptive decision making, variation in COMT and 5-HTTLPR, and substance use outcomes in high-risk individuals. Journal of Studies on Alcohol and Drugs 75: 643-652, 2014. PMID: 24988263 Read Article
Hill SY, Jones BL, Zezza N, Stiffler S. Family-based association analysis of alcohol dependence implicates KIAA0040 on chromosome 1q in multiplex alcohol dependence families. Open Journal of Genetics 3: 243-252, 2013. PMID: 24829844 Read Article
Hill SY, Weeks DE, Jones BL, Zezza N, Stiffler S. ASTN1 and alcohol dependence: Family-based association analysis in multiplex alcohol dependence. Am J Med Genet Part B (Neuropsychiatr Genet) 159B: 445-455, 2012. PMID:22488871 Read Article
Creswell KG, Sayette MA, Manuck SB, Ferrell RE, Hill SY, Dimoff JD. DRD4 polymorphism moderates the effect of alcohol consumption on social bonding. PLOS One e28914, 2012. PMID: 22347363 Read Article
Hill, SY, Wang S, Carter H, Tessner K, Holmes B, McDermott M, Zezza N, Stiffler S. Cerebellum volume in high-risk offspring from multiplex alcohol dependence families: Association with allelic variation in GABRA2 and BDNF. Psychiatry Research: Neuroimaging 194: 304-313, 2011. PMID:22047728 Read Article
Hill SY, Hoffman EK, Zezza N, Thalamuthu.A, , Weeks DE, Matthews A. Mukhopadhyay I. Dopaminergic mutations: Within-family association and linkage in multiplex alcohol dependence families. Am J Med Genet Part B (Neuropsychiatr Genet) 147B: 517-526, 2008. PMID:17948902 Read Article
Matthews AG, Zezza N, Stiffler S, Hill SY. The Role of the GABRA2 Polymorphism in Multiplex Alcohol Dependence Families with Minimal Comorbidity: Within-Family Association and Linkage Analyses. Journal of Studies on Alcohol and Drugs 68: 625-634, 2007. Read Article
Hill SY, Shen S, Zezza N, Hoffman EK, Perlin M, Allan W: A genome-wide search for alcoholism susceptibility genes. Am J Med Genet Part B (Neuropsychiatr Genet) 128B: 102-113, 2004. Read Article
Hill SY, Zezza N, Wipprecht G, Locke J, Neiswanger K: Personality traits and dopamine receptors (D2 and D4): Linkage studies in families of alcoholics. Am J Med Genet (Neuropsychiatr Genet) 88: 634-641, 1999. Read Article
Hill SY, Zezza N, Wipprecht G, Xu J, Neiswanger K: Linkage studies of D2 and D4 receptor genes and alcoholism. Am J Med Genet (Neuropsychiatr Genet) 88: 676-685, 1999. Read Article
Selected MRI Publications:
Sharma VK, Hill SY. Differentiating the effects of familial risk for alcohol dependence and prenatal exposure to alcohol on offspring brain morphology. Alcohol Clin Exp Res. 41:312-322, 2017. PMID:28084631 Read Article
O’Brien JW, Hill SY. Neural predictors of substance use disorders in young adulthood. Psychiatry Res Neuroimaging. 268:22-26, 2017. PMID:28843088 Read Article
Hill SY, Lichenstein SD, Wang S, O’Brien J. Volumetric differences in cerebellar lobes in individuals from multiplex alcohol dependence families and controls: their relationship to externalizing and internalizing disorders and working memory. Cerebellum 15:744-754, 2016. PMID:26589810 Read Article
Hill SY, Wang S, Carter H, McDermott M, Zezza, Stiffler S, Lichenstein S. Amygdala volume in offspring from multiplex for alcohol dependence families: The moderating influence of childhood environment and 5-HTTLPR. Journal of Drug and Alcohol Dependence S1:001, 2013. PMID: 25285331 Read Article
Hill SY, Lichenstein SL, Wang S, Carter H, McDermott M. Caudate volume in offspring at ultra high risk for alcohol dependence: COMT Val158Met, DRD2, externalizing disorders, and working memory. Advances in Molecular Imaging 3: 43-54, 2013 PMID:25364629 Read Article
Hill SY, Terwilliger R, McDermott MD. White matter microstructure, alcohol exposure, and familial risk for alcohol dependence. Psychiatry Research: Neuroimaging 212: 43-53, 2013. PMID:23473988 Read Article
Hill SY, Tessner K, Wang S, Kostelnik B, Carter H, Holmes B, McDermott M: Temperament at 5 years of age predicts amygdala and orbitofrontal volume in the right hemisphere in adolescence. Psychiatry Research: Neuroimaging 182: 14-21, 2010. PMID:20236805 Read Article
Tessner K and Hill SY. Neural circuitry associated with risk for alcohol dependence. Neuropsychology Reviews 20: 1-20, 2010. PMID:19685291 Read Article
Hill SY, Wang S, Kostelnik B, Carter H, Holmes B, McDermott M, Zezza N, Stiffler S, Keshavan MS. Disruption of orbitofrontal cortex laterality in offspring from multiplex alcohol dependence families. Biological Psychiatry 65: 129-136, 2009. PMID: 18986649 Read Article
Hill SY, Muddasani S, Prasad K, Steinhauer S, Scanlon J, McDermott M, Keshavan M. Cerebellar volume in offspring from multiplex alcohol dependence families. Biological Psychiatry 61: 41-47, 2007. Read Article
Hill SY, Kostelnik B, Holmes B, Goradia, D, McDermott MD, Diwadkar, V, Keshavan MS. fMRI BOLD Response to the Eyes Task in Offspring from Multiplex Alcohol Dependence Families. Alcoholism: Clinical and Experimental Research 31: 2028-2035, 2007. Read Article
Hill SY, Kostelnik, B, Wang Shuhui, Nutche J, McDermott M, Diwadkar V Keshavan M. Affective Circuitry in Unaffected Adolescent/Young Adult Offspring from Multiplex Alcohol Dependence Families: Structural and Functional MRI Studies. Neuropsychopharmacology 31: S204, 2006. Read Article
Hill SY, DeBellis MD, Keshavan MS, Lowers L, Shen S, Hall J, Pitts T: Right amygdala volume in adolescent/young adult offspring from families at high risk for developing alcoholism. Biological Psychiatry 49: 894-905, 2001. Read Article
Selected Biological Risk Factors Publications:
Hill SY, O’Brien JW: Psychological and neurobiological precursors of alcohol use disorders in high risk youth. Current Addiction Reports 2: 104-113, 2015. PMID: 26301172 Read Article
O’Brien JW, Hill SY. Effects of Prenatal Alcohol and Cigarette Exposure on Offspring Substance Use in Multiplex, Alcohol-Dependent Families. Alcoholism: Clinical and Experimental Research 38: 2952-2961, 2014. PMID: 25581650 Read Article
Hill SY, Tessner KD, McDermott MD: Psychopathology in offspring from families of alcohol dependent female probands: A prospective study. Journal of Psychiatric Research 45: 285-294, 2011. PMID:20801463 Read Article
Hill SY: Neural Plasticity, human genetics, and risk for alcohol dependence. In Functional Plasticity and Genetic Variation. Edited by Reilly MT and Lovinger DM. International Review of Neurobiology v 91, pp. 53-94, Academic Press, 2010. PMID:20813240 Read Article
Hill SY, Steinhauer SR, Locke-Wellman J, Ulrich R. Childhood risk factors for young adult substance dependence outcome in offspring from multiplex alcohol dependence families. Biological Psychiatry 66: 750-757, 2009. PMID:19640504 Read Article
Hill SY, Shen S, Lowers L, Locke-Wellman J, Matthews AG, McDermott M. Psychopathology in offspring from multiplex alcohol dependence families: A prospective study during childhood and adolescence. Psychiatry Research 160:155-166, 2008. PMID: 18597856 Read Article
Hill SY, Shen S, Locke-Wellman J, Rickin E, Lowers L. Offspring from families at high risk for alcohol dependence: Increased body mass index in association with prenatal exposure to cigarettes but not alcohol. Psychiatry Research 135: 203-216, 2005. Read Article
Shen S, Locke-Wellman J, Hill SY: Adolescent alcohol expectancies in offspring from families at high risk for developing alcoholism. J Stud Alcohol 62: 763-772, 2001. Read Article
Hill SY, Shen S, Locke J, Lowers L, Steinhauer S, Konicky C: Developmental changes in postural sway in children at high and low risk for developing alcohol-related disorders. Biological Psychiatry 47: 501-511, 2000. Read Article
Hill SY: Biologic phenotypes associated with individuals at high risk for developing alcohol-related disorders. Addiction Biology 5: 5-22, 2000. Read Article
Hill SY, Shen S, Lowers L, Locke J: Factors predicting the onset of adolescent drinking in families at high-risk for developing alcoholism. Biological Psychiatry 48: 265-275, 2000. Read Article
Hill SY, Lowers L, Locke J, Shen S: Maternal smoking and drinking during pregnancy and the risk for child and adolescent psychiatric disorders. J Stud Alcohol 61: 661-668, 2000. Read Article
Hill SY, Lowers L, Locke J, Snidman N, Kagan J: Behavioral inhibition in children from families at high risk for developing alcoholism. J Am Acad Child Adolesc Psychiatry 38: 410-417, 1999. Read Article
Hill SY, Locke J, Lowers L, Connolly J: Psychopathology and achievement in children at high risk for developing alcoholism. J Am Acad Child Adolesc Psychiatry 38: 883-891, 1999. Read Article
Selected ERP Publications:
Hill SY. Jones BL, Holmes B, Steinhauer SR, Zezza N, Stiffler S, Cholinergic receptor gene (CHRM2) variation and familial loading for alcohol dependence predict childhood developmental trajectories of P300. Psychiatry Research 209: 504-511, 2013. PMID:23747232 Read Article
Hill SY, Shen S: Neurodevelopmental patterns of visual P3b in association with familial risk for alcohol dependence and childhood diagnosis. Biological Psychiatry 51: 621-631, 2002. Read Article
Hill SY, Yuan H, Locke J: Path analysis of P300 amplitude of individuals from families at high and low risk for developing alcoholism. Biological Psychiatry 45: 346-359, 1999. Read Article
Hill SY, Shen S, Locke J, Steinhauer SR, Konicky C, Lowers L, Connolly J: Developmental delay in P300 production in children at high risk for developing alcohol-related disorders. Biological Psychiatry 46: 970-981, 1999. Read Article